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What is PT-141?
PT-141 (Bremelanotide) is a centrally acting melanocortin receptor agonist used to enhance sexual desire and arousal in both men and women. Originally developed to treat sexual dysfunction, it is FDA-approved for hypoactive sexual desire disorder (HSDD) in premenopausal women and is also commonly used off-label in men with low libido or erectile dysfunction—especially when psychological or central causes are suspected. Unlike traditional ED medications, PT-141 works through the brain rather than blood flow.
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Frequently Asked Questions
What can I expect with PT-141 treatment?
• Inject 1 hour before sexual activity (typically 1.75mg dose)
• Onset: 45–60 minutes, duration: 6–12 hours
• Do not exceed 1 dose in 24 hours or 8 doses per month (per FDA guidelines for women)
• Results improve with repeated, consistent use over time
• Safe to combine with TRT, HRT, or PDE5s (under supervision)
• Missed dose? PT-141 is on-demand—only use when needed
What are the possible side effects of PT-141?
Common Side Effects:
• Nausea (transient)
• Flushing or warmth
• Headache
• Injection site reactions
Less Common / Monitor If Present:
• Elevated blood pressure (temporary)
• Fatigue or yawning
• Dizziness
• Darkening of gums or skin (rare with prolonged use)